Abstract

PREPARATION AND EVALUATION OF SODIUM DICLOFENAC LOADED CHITOSAN CONTROLLED RELEASE MICROPARTICLES USING FACTORIAL DESIGN

Sodium diclofenac is a non-steroidal anti-inflammatory drug used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis. Chitosan is a linear polysaccharide derived from chitin that has been used in different pharmaceutical forms and drug delivery systems. The purpose of this study was to prepare and evaluate the chitosan beads as a controlled drug release system for sodium diclofenac consists of sustained release microparticles and immediate released particles. Sustained release chitosan microparticles were prepared with an ionic cross-linking agent. Loading efficiency was influenced by percentage of sodium polyphosphate, Tween and drug-chitosan proportion with the maximum amount of 83.12%. Release of sodium diclofenac from microparticles pattern indicated burst and sustained release that was influenced by percentage of Tween 80. Finally, Chitosan microparticles provided suitable sustained release and drug loading for sodium diclofenac oral delivery


Author(s): Behzad Sharif Makhmal Zadeh,, Fatemeh Moshtaghi , Fakher Rahim , Abbas akhgari

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