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Nephroprotective Effect of Amaranthus spinosus Root Extract in Carbon Tetrachloride Induced Histological Toxicity in Male Albino Rat

In the present study, ethanol extract of Amaranthus spinosus root was investigated for protective activity in CCl4 induced nephrotoxicity in male albino rat by histological assessment. CCl4 induced intoxicated rats were treated with 150, 300 and 450 mg/kg body wt. dose of ethanol extracts of A. spinosus in 15 days’ experimental schedule. The results revealed the deleterious histopathological alterations in kidney associated with glomerular and tubular degenerations in CCl4 intoxicated rat. Treatment of A. spinosus roots especially at 450 mg dose protects the kidney by improving disrupted metabolisms and antioxidant defense against CCl4 induced oxidative damage in 15 days’ protective experimental schedule. The findings support the therapeutic use of A. spinosus in ailments caused by oxidative and altered metabolisms.


Suryakant Kengar, Dattatray Thorat and Jaywant Jadhav

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