The ethanol extracts of the whole plant Sphaeranthus indicus Linn. (ALSI) (Compositae) was tested for anti-ulcer by aspirin plus pylorous ligation induced ulcer. The test extracts were tested at 250 mg and 500 mg/kg body weight. The antiulcer activity was assessed by keeping ranitidine 50 mg/kg as standard drug. The parameters studied were gastric volume, free acidity, total acidity, and ulcer index. The antiulcer activity was significant with the test extracts. In aspirin plus pylorus ligation method ALSI pretreated animal showed significant reduction in gastric volume, free acidity, total acidity, and ulcer index. The ulcer protection of the extract was found to be 82.9% and 85.3%, whereas the standard drug ranitidine showed 92.6%. The result suggested that ALSI possess significant and dose dependent anti ulcer activity.