The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Immune Response Regarding Hepatitis C

Purpose of review: Hepatitis C virus infection and the immune response in babies and adults. Findings: The presence of MDSCs in new-borns makes Hepatitis C chronic in the first years of life in the case of exposure to virus. The expansion of MDSCs allows the immune system to maintain the chronic infection with Hepatitis C because MDSCs are responsible for the disfunction of the immune system and not the virus itself. MDSCs express CTLA-4, who is a protein receptor that functions as an immune checkpoint and down-regulates immune responses. The expression of the CTLA-4 protein in the lymph node allows the manifestation of hepatitis C and allows the inhibition of T cells against HCV RNA. Summary: MDSCs are responsible for chronic Hepatitis C infection. The expansion of MDSC is the format in which hepatitis C manages to escape the immune system’s response. Inhibitory protein CTLA-4 expressed by MDSCs in lymph node maintain hepatitis C infection. MDSCs cells have the ability to interact with these signals generated by common progenitor lymphoid cells and in this way the immune system cannot exercise its function.


Cosmin Constantin Oprea

Abstract | PDF

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