Solubility is a major problem for the successful development and commercialization of new drug products. At present about 40% of drugs in the development pipelines and approximately 70% of drugs coming from synthesis are poorly soluble. Number of approaches are available for addressing the issues of low aqueous solubility. Among them nanosuspension has gain popularity in pharmaceutical industry in the last 10 years, because of their unique advantages. Nanosuspensions are defined as sub-micron colloidal dispersions of nanosized pure drug particles that are stabilized by a suitable polymer and/or surfactant and have a particle size of 1–1000 nm. Top-down and bottom-up technologies are the two primary approaches for nanosuspension production. This review article focus on different top-down and bottom-up technologies for the production of nanosuspension. The core objective of this review article is to focus on different critical variables affecting functional properties of nanosuspension.