Reach Us 44-7452-259145


The application of Plackett-Burman design and response surface methodology for optimization of formulation variables to produce Piroxicam niosomes

The aim of the present study were (1) to screen seven independent variables (X) including; speed of rotation (X1), amount of chloroform (X2), HLB (X3), PIR amount in buffer (X4), sonication time (X5), total lipid amount (X6), and surfactant cholesterol ratio (X7) using Plackett-Burman design to identify which variables significantly affect the entrapment efficiency (EE%) and in-vitro release (Y) of PIR niosomes; and (2) to optimize the formulation by response surface methodology (RSM). PIR niosomes were prepared by lipid evaporation method and all vesicles were evaluated for their particle size, EE%, and in-vitro drug release. The niosomes appeared as round in shape and size ranged between 97.85 and 161.25nm. EE% was found to be between 20.23% and 37.13%. The release profiles of PIR niosomes occurred in two distinct phases, an initial phase for about 8 hours, followed by slow phase for at least 4 hours. The in-vitro study suggests that higher EE% was related with slow release. The release pattern shown by these formulations were Higuchi diffusion controlled mechanism. RSM showed that X3, X7, and X6 had the main effect on the responses (Y).

Author(s): Ahmed M.S. Ahmed, Mamdouh M. Ghourab, Shadeed Gad, and Mona K. E. Qushawy

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Google scholar citation report
Citations : 7472

International Journal of Drug Development and Research received 7472 citations as per google scholar report

International Journal of Drug Development and Research peer review process verified at publons
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image


tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet

rolex replica