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Synthesis of hydrazine based novel HMG coA inhibitor and its docking studies

Heart attack is the recent attention to the medical sciences and cardiac low density cholesterol (LDL) has a significant role in inhibiting the arrest. Various pathways having the keypoints which can interrupt the synthesis of bad cholesterol. In this study Hydrazine based compound is choosen due to its wide applications, the 1,2-Bis (2-hydroxy-5-methylbenzylidene) - hydrazine crystals were synthesized. It was taken as a ligand for molecular docking. The target receptor used for docking is HMG-CoA reductase whose crystal structure is available on the PDB database as PDB ID: 1DQ8. For docking analysis, Autodock tool v4. 2 program used. The synthesized crystals are subjected to single crystal X-ray studies in order to investigate their molecular structure.

Author(s): Saravanan. B, Akhilesh Upgade, Saravanan R. R, Manivannan.V

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