Abstract

SYNTHESIS OF BIS-PYRIMIDO IMIDAZOLE FUSED RING HETEROCYCLIC ADDUCTWITH UREAS OF MANNICH BASE FOR CNS DEPRESSION

Mannich bases as well as urea derivatives have potent CNS depression activity. In our project work we have chosen a CNS drug which blocks the GABA receptor as well as chloride channel. Benzodiazepines have closed chain amide linkage which acts on GABA (gamma amino butyric acid) receptor and produces CNS depression with the blockage of chloride channel. This receptor has free amino and carboxylic acid functional group which produces amide linkage in-vivo.


Author(s): AVANI H. SHETH, PARIMAL M. PRAJAPATI, YATRI R. SHAH AND DHRUBO JYOTI SEN

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