The synthesis of derivative precursors for pharmaceutically established cardiovascular drug substance that is Atorvastatin Calcium has been carried out with eco-friendly and conventional method. The synthesis process has been designed in such a way that can be easily commercialized or scaled up in any pharmaceutical industry. The ultimate goal of research is to make available the technology for the cheap and effective production of cardiovascular pharmaceutical ingredients. In tune on above four compounds has been synthesized, characterized and reported in this paper. The quality of the products has been established by using modern spectroscopic and physicochemical tools for analysis that includes: Mass, IR, NMR, HPLC, Melting point CHN analysis etc.