Abstract

SYNTHESIS AND CHEMISTRY OF PYRAZOLONE WITH PYRIMIDINE RING AND SCREENING OF ANTIOXIDANT ACTIVITY OF SYNTHESISED HETEROCYCLIC NUCLEUS HAVING UREA/THIOUREA/GUANIDINE LINKAGES

Five member pyrazolone and six member pyrimidine nucleus have been synthesised by multistep synthesis and subjected for antioxidant study for variable electronegative atoms for X=O(urea)/S(thiourea)/NH(guanidine). In-vitro antioxidant activity by reducing power indicated that incresed absorbance with concentration of showed that synthesized compounds have reducing power. By Ferric reducing antioxidant power (FRAP) assay method, it has been concluded that the three synthesized compound are responsible for the antioxidant potential: Compound-C (X=NH) >Compound-B (X=S) >Compound-A (X=O)


Author(s): Dilip R. Chavda, Priya R. Modiya, Hiren M. Marvaniya and Prof. Dr. Dhrubo Jyoti Sen

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