Synthesis and Anti-Microbial Potential of Novel Imidazolinone Derivatives of Benzothiazole

Human kind has been subject to infection by microorganism since before the dawn of recorded history. Survey of Literature reveals that no sufficient work regarding synthesis of imidazolinone derivatives of 2-aminobenzothiazole has been reported. They have been found effective in the treatment of cancer, tuberculosis etc. Therefore the present research was designed to synthesize the new imidazolinone derivatives of benzothiazole and to evaluate its antimicrobial effect. The benzothiazole derivative was synthesized and its pharmacological potential was evaluated by disc diffusion method against Gram positive and Gram bacteria. Two strains were used in test including Gram +ve- Bacillus subtilis, Staphylococcus aureus and Gram -ve E. coli, Pseudomonas aeruginosa. In result, they significantly exhibited antimicrobial and anti-fungal potential when tested against all species. The effect was found in the dose dependent manner. In conclusion, it suggests evaluating its effect on some other types of bacteria and spores for better prevention of bacterial and fungal infections. It might be used in the treatment of microbial infections.


Swati Gupta, Singh DCP, Shadma Chisti Mohd Asif Khan and Deeksha Sahai

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