Abstract

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 5-METHYLPYRAZINE-2- CARBOHYDRAZIDE DERIVATIVES

Here an attempt has been made to synthesize fourteen 5-methylpyrazine-2-carbohydrazide derivatives. The synthesized derivatives were assessed for their in-vitro anti-bacterial activity and minimum inhibitory concentration (MIC) against Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) and Gram-negative strains (Salmonella typhi and Escherichia coli). During the present work, 5-methylpyrazinoic acid was esterified with ethanol to get ethylpyrazinoate and it refluxed with hydrazine hydrate to yield the 5-methylpyrazinoic acid hydrazide. The obtained acid hydrazide was then condensed with various substituted aromatic aldehydes to yield various 5-methylpyrazine-2- carbohydrazide derivatives. The structures of newly synthesized compounds so obtained were confirmed by using IR, 1HNMR, MS spectral data. All compounds gave satisfactory elemental analyses. The compounds PM 8-10, (i.e. 2,3 and 4- nitro benzaldehyde derivatives respectively) showed promising activity amongst the compounds tested against both the Gram-positive and Gram-negative strains tested. .


Author(s): MINIYAR P. B. AND MAKHIJA S. J.

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

tempobet

tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet
https://www.galaxyshell.com/
https://wowcappadocia.com
https://cappadocia-hotels.com
https://balloon-rides.net
https://pmasites.com/https://casinositeleriniz.com/https://fbhesq.com/
https://babesoflondon.com/

https://paperio-live.com

rolex replica

https://naughtyworms.com