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Study of Kinetic rates of Medical product with Antimicrobic action by In Vitro method

Kinetic parameters of medical product under study with contents of metronidazole and quinosol designed for medical treatment of patients of gynaecological profile are uncovered in the given article. Degree of active pharmaceutical ingredients release from dosage forms is determined in in vitro experiments. It was found out that kinetic processes of release run according to first order equation, and velocity of release process decreases when increasing the half-value period, which attests process slowing-down. According to determined periods of metronidazole and quinosol halfvalue from processed gel and cream, the degree of prolongation of developed products action was established. According to the results of kinetic research it was proved that the highest prolongation in the series of developed medical products was shown by cream and the lowest – by gel.

Author(s): Yulia Polischuk, Anna Drozdova, Elena Davtyan, Zoryana Maletska

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