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Spectrochemical study of a new albendazole derivative

The hydatidosis is a cosmopolitan parasitic disease that stays a real public health problem in the countries of strong endemic. The treatment essentially calls on the surgery that includes morbidity and mortality significant, from where the interest to develop the medical treatment whose main representative is the albendazole. The efficiency of this molecule is proven but limited by its bad biodisponibility due to its weak absorption by the organism. In order to improve the biodisponibility of this molecule we synthesized an ester prodrug of albendazole to solubility completely modified in relation to the princeps. This synthesis has been achieved with an output of 75%. The structure of the synthesis product has been verified and established by spectrometry of infrared molecular absorption, and by spectrometry of nuclear magnetic resonance of the proton.

Author(s): El harti Jaouad, Taoufik Jamal, Ansar Mhammed

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