Simple UV Spectrophotometric method development and Validation for determination of Lacosamide in bulk and its Tablet Dosage Form

A simple and reproducible UV spectroscopic methods have been developed and validated for the determination of lacosamide (LCM) in bulk and tablet dosage forms of two different brands. The standard and sample solutions were prepared using methanol: water (50:50 % v/v) as solvent. The maximum absorbance was obtained at 257 nm. Beer’s Lambert’s law was obeyed at the concentration range of 400 – 600 μg/ml and the correlation coefficient was found to be 0.9996. The developed method was validated according to ICH guidelines and was found to be accurate and precise for the determination of lacosamide in bulk and its tablet dosage form.

Author(s): R.Valarmathi, S.Farisha Banu, R.Senthamarai, C.S. Dhivya Dhharshini

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