Abstract

SELF EMULSIFYING DRUG DELIVERY SYSTEM: A CONVENTIONAL AND ALTERNATIVE APPPROACH TO IMPROVE ORAL BIOAVAILABILITY OF LIPOPHILIC DRUGS

Out of newly discovered drugs most of the drugs are found to be lipophilic and out of which up to 40 % of pharmacologically active new molecules failed to reach to market only due to little or no water solubility; a serious challenge for the successful development and commercialization of new drugs in the pharmaceutica lindustry. Therefore various formulation strategies have been investigated to improve the solubility and the rate of dissolut ion to enhance the oral bioavailability of lipophilic drugs. Amongst various approach self emulsifying drug delivery system has gained more attention due to enhanced oral bio-availability enabling reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug(s) toward specific absorption window in GIT, and protection of drug(s) from the hostile environment in gut. The present review discussed the mechanisam of self emulsification, composition, formulation approaches, different techniques, evaluation, factors affecting SEDDS, advantages, draw backs, applications and future trends in SEDDS.


Author(s): Patel Vipul P. Desai Tushar R, Kapupara Pankaj P, Atara Samir A, Keraliya Rajesh A

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