Abstract

Self- Assembled Chitosan-g-Pluronic F-127 Copolymer (ChPC) Loaded with Polydatin Nanoparticles: Implication as Anti-Diabetic Therapy

Our aims to develop a safe and effective polymeric nano-template for assessing pharmaceutical potentialities in modulating the drug profile in the field of anti-diabetes research. We rationally aimed to design the Chitosan (Ch) grafting with PF as co-polymer (ChPC). The FT-IR, dynamic light scattering, SEM, TEM and % entrapment efficacy are commenced to examine the efficacy of the prepared nanoparticles in successful Polydatin (PD) delivery (PD-ChPC-NPs) having average particle size 263 ± 1.25 nm with PDI 0.162. The PD-ChPC-NP has a spherical in shape and can be loaded with high encapsulation efficiency (86.49 ± 0.29). It was observed that PD-ChPC-NP was stable at various temperatures and biocompatibility. In vivo animals studies have also clearly shown that compared with free PD, PD-CSNP has a significant anti-diabetic effect in diabetic rats. To conclude, the current research shows that PD-ChPC-NPs represent potentially safe nanocarriers that can be used for non-toxic and effective treatment of diabetes.


Author(s):

Xiaoling Tian1, Dongliang Zhu2*, Li Chen1, Manhua Liu3 and Xiufen Liu4



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