Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial, temporal and smart delivery and increasing patient compliance. These systems are designed according to the biological rhythm of the body. Here drug delivery is facilitated according to disease rhythm. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, single and multiple-unit systems based on the use of soluble or erodible polymer coating and use of rupturable membranes have been dealt with in the article. It summarizes the latest technological developments, formulation parameters, and release profiles of these systems. These systems are beneficial for the drugs having chronopharmacological behavior such as drug used in treatment of rheumatoid arthritis, osteo arthritis and ankylosing spondylitis like inflammatory disorders. Current review article discussed the reasons for development of pulsatile drug delivery system, types of the disease in which pulsatile release is required, classification, evaluations, advantages, limitation, and future aspects of pulsatile drug delivery system.