Hepatotoxicity is one of the main side effects associated with Doxorubicin (DOX) treatment. The aim of the present study was to examine the protective effect of S. torvum in Doxorubicin (DOX) induced hepatotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or Solanum torvum (100 mg/kg and 300 mg/kg, p.o.) prior to DOX or S. torvum (100 mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Hepatotoxicity was assessed in rats by recording changes in biochemical and histopathological approaches. Abnormal levels of transaminases (ALT and AST) in blood and the antioxidant defence enzymes superoxide dismutase (SOD) and catalase (CAT) for liver were measured at the end of the treatment schedule. Treatment with S. torvum (100 mg/kg and 300 mg/kg) significantly (p<0.05) decreased the levels of ALT, AST, and increased the anti-oxidant defence enzyme levels of SOD and CAT. Histopathological changes showed that DOX caused significant structural damages to liver like inflammation, congestion and necrosis which was reversed with S. torvum. The results suggest that S. torvum has the potential in preventing the organ toxicity induced by Doxorubicin.