Liver is highly vulnerable to damage because of its critical role in the transformation and clearance of chemicals. Hepatotoxicity is the prime factor responsible for drug withdrawal from the market. There is no doubt that hepatotoxicity requires considerable attention and that every viable measure be taken towards an efficient mechanism for hepatoprotection. The primary areas of focus for hepatoprotective therapies encompass better targeting, stability and better bioavailability. Such focus areas can be effectively met with the aid of lipid based delivery systems which can prove to be a breakthrough in the field of hepatoprotection.