Phytochemistry and in vitro Studies on Anti-Fertility Effect of Ficus religiosa Fruits Extract on Uterine Morphology of Goat (Capra hircus)

Use of herbal methods for fertility regulation is widely accepted alternative for the synthetic drugs containing chemical having side effects. Ficus religiosa is a large evergreen tree found throughout India, wild as well as cultivated. It is a highly apparent plant in Ayurvedic system of medicine for the treatment of various ailments. No report is available on the antifertility activity of plant extract hence; the present study was carried out to investigate the same.The phytochemical analysis was done using GC-MS. The compound detection employed the NIST Ver. 2.0 - Year 2008 library. The results of the GC-MS analysis provide different peaks determining the presence of many phytochemical compounds with different therapeutic activities. The major phytoconstituents were n-Hexadecanoic acid; 9, 12-Octadecadienoic acid; 9, 12, 15-Octadecatrienoic acid, and Butyl 9, 12, 15-octadecatrienoate.Effects of 1% methanol extract of fruits extract was studied on the goat uterus in vitro in exposure duration dependent manner (1 hour, 4 hours and 8 hours). Effects on dimensions of uterine glands, surface epithelium, gland cell and myometrium were observed. The treatment induces a decline in uterine glands diameter which are crucial for implantation. Present observations suggest that the extract has antifertility activity and should be experimented for antifertility programme.

Author(s): Goyal A. K

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