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Optimization of Granulation and Compression process Variables of Atenolol Tablets using Box-Behnken Design

Pharmaceutical tablets represent the most popular drug delivery systems. Tablets are manufactured by compressing a powder formulation in a die. Following this process the tablets are subjected to a bulk handling and other operations during which the bioavailability (disintegration, dissolution) behaviour and mechanical integrity must be maintained. The final properties of the tablets depend on the choice of ingredients used in the powder formulation, the details of the mixing process and selection of process parameters applied by tabletting equipment. The application of three or higher-level experimental design using the response surface methodology does not appear to have been reported in development and optimization of drug release methods until now. The relationship between one or more response variables and set a quantitative parameters can be examined well by using response surface models , such as central composite design or Box-Behnken design. In this present work systemic analyses of the process parameters during compression process and explore their influence on the final properties of the tablets have been studied. Also illustrate how tablet properties are controlled by dependent variables of granulator and compression machine.

Author(s): Tarak J. Mehta, Mohan Mothilal, Alpesh D. Patel, Mukesh R. Patel, Dr K.R.Patel Natvarlal M. Patel

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