Molecular docking studies of Ellagic Acid and Gallic Acid In diabetic Nephropathy

The chronic diabetes mellitus leads to diabetic nephropathy, which is one of the major microvascular complication of end stage renal disease worldwide and causes premature death in diabetic patients. The objective of the present investigation was to evaluate the protective effect of phytoconstituents, Ellagic acid and Gallic acid of seeds of Eugenia jambolana in diabetic nephropathy by dry lab studies. The nephroprotective effect was studied by molecular docking method using 108 A diabetic nephropathy protein. The results of docking studies revealed that Ellagic acid and Gallic acid showed the bonding score of - 8.05708 Kcl/mol and -6.67303 Kcl/mol, for 108 A nephropathy protein for being a good nephro protective in diabetic nephropathy complications.The findings of this investigation concluded that Ellagic acid and Gallic acid has potential protective effect in diabetic nephropathy.

Author(s): GodwinSelvarajEsther, Alvin JoseManonmani

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