The present study describes a simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of Venlafaxine hydrochloride, an antidepressant drug in bulk and pharmaceutical dosage form. The solvent used was Water and Methanol in the ratio of 50:50 and the λmax or the absorption maxima of the drug was found to be 227nm. A linear response was observed in the range of 4-70μg/ml with a regression coefficient of 0.999. The method was then validated for different parameters as per the ICH (International Conference for Harmonization) guidelines. This method can be used for the determination of Venlfaxine in quality control of formulation without interference of the excipients.