Mathematical Models of the Pharmacokinetic Behavior of Clindamycin in Healthy Subjects after Oral Administration of 150 mg of Clindamycin

The goal of the current study was to provide a further example of a successful use of a non-traditional modeling method in the development of mathematical models in pharmacokinetics. The current study is a companion piece of the earlier study by Forist et al. published in February issue of Journal of Pharmacokinetics and Biopharmaceutics, therefore the data published in the study cited here were used. All mathematical models developed, successfully described the data of all healthy male volunteers enrolled in the study by Forist et al. and in the current study. The modeling method used in the current study is used to developed mathematical models of dynamic systems not only in pharmacokinetics but also in several other scientific and practical fields.


Mária Durišová

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