Isolation, Characterization and In vitro Antiurolithiatic activity of Cerpegin Alkaloid from Ceropegia bulbosa var. Lushii root

Ceropegia bulbosa var.lushii also known as Kadula, Haudlo, Khappar-kaddu, Bhuu-tumbi, Gilodya and Patalatumbi in local language, family Asclepiadaceae. The tuberous roots are used to treat several diseases like diarrhoea, dysentery, analgesic, antipyretic, kidney stone and other activities. The tuberous root contains steriods, polyphenols, fats, albuminoids, sugars, potassium and active constituent an alkaloid cerpegin.The present investigation was carried out to isolate, purify and characterize cerpegin from root of Ceropegia bulbosa var.lushii. The isolated cerepegin was further characterized with the help of Ultraviolet Spectroscopy, Thin Layer Chromatography, Attenuated Total Reflectance Spectroscopy, Mass Spectroscopy, Proton- Nuclear Magnetic Resonance Spectroscopy confirmed the identification. The antiurolithiatic activity of cerpegin was evaluated by using modified invitro model. The isolated compound cerpegin (A1) was showed maximum dissolution of both types of stones (calcium oxalate and calcium phosphate) in comparison to the all extract tested. Cystone was found to be more effective.

Author(s): Jain Monika, Bhandari Anil, Bhandari Aakanksha, Patel Priyanka

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