Isolation, Characterization and Antibacterial activity of 4-(4-phenyl-1, 4-dihydronaphthalen-1-yl) Pentenoic Acid from the Stem Bark of Brachystegia eurycoma Harms

A new napthalene pentenoic acid identified as 4– (4–phenyl-1,4-dihydronaphthalen-1-yl) pentenoic acid was isolated from ethanol extract of the stem bark of Brachystegia eurycoma Harms. The structure of the compound was elucidated using Infrared Spectroscopy, Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry. The isolated compound showed marked antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Streptococcus fecalis. These results provide a corroborative evidence for the use of Brachystegia eurycoma stem bark in the treatment of gonorrhea and other infections including healing of wounds in herbal medicine in Nigeria.

Author(s): Okenwa U. Igwe and Johnbull O. Echeme

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