Propranolol HCl, an antihypertensive drug was formulated as transdermal prolonged release proniosomal gel due its drawback of short life when given through oral route. Nine formulations of proniosomes were prepared using different polymers viz. Maltodextrin, span 40, span 60 and cholesterol by slurry, slow stirring method. All were in turn prepared as proniosomal gels by using carbapol 940 by simple stirring. Gels were evaluated for entrapment efficiency, In-vitro skin permeation studies, scanning electron microscopy (SEM) analysis, vesicle size analysis, drug excipient interaction studies. Different release models like zero order, first order, Higuchi, Korsmeyer-peppas etc were applied to in-vitro drug release data in order to evaluate the drug release mechanisms and kinetics. Among all proniosomal transdermal gel formulation, F5 produced from pronisomal powder containing 10mg of Propranolol HCl , 100mg of cholesterol, 100mg of maltodextin, Span 40 and Span 60 each of 250mg exhibited ideal diffusion characteristics of 20.25% release at 2nd hr followed by controlled release for 12 hrs with 80.5% release at 12th hr. In-vivo evaluation of pharmacokinetic evaluation exhibited remarkable enhancement of elimination half life up to 13.08 hrs.