Reach Us 44-7452-259145

Abstract

Investigation of Darunavir resistance against triple mutant (V32I, I47V and V82I) in HIV-1 protease by molecular simulation approach

The HIV-1 Protease has been a critical drug target for war against AIDS and recently many protease inhibitors have been developed which inhibit the action of protease enzyme and prevent infection of HIV. However site-specific mutations occurring at one or more residues in HIV-1 protease has caused the development of resistance to protease inhibitors. In the present study, we have investigated the binding affinity of Darunavir to HIV-1 protease triple mutant (V32I, I47V and V82I) using bioinformatics approach. We have also highlighted the effect of mutations on the binding site residues and flap comprising residues in the HIV-1 protease by means of flexibility analysis. Molecular dockings were performed in order to gain insights into the binding mode of the Darunavir with HIV-1 protease structure. Subsequently, the docking results were also validated by means of PEARLS program. We hope that these results certainly will be helpful for the better understanding of mechanism of drug resistance.


Author(s): Rahul Jain, K. Ramanathan*

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Google scholar citation report
Citations : 7472

International Journal of Drug Development and Research received 7472 citations as per google scholar report

International Journal of Drug Development and Research peer review process verified at publons
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image

tempobet

tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet
https://wowcappadocia.com
https://cappadocia-hotels.com
https://balloon-rides.net

https://paperio-live.com

rolex replica

https://agario.red

https://naughtyworms.com

Vaporesso
Smok
https://www.unitedluxury.net/