Reach Us 44-7452-259145


In-Silico Docking studies for the Comparative Analysis of Natural and Synthetic Compounds against Leptospira Interrogans

Pathogenic species of Leptospira cause leptospirosis, a global zoonotic disease. Leptospirosis continues to have major impacts on people of developing countries with inestimable morbidity and mortality. Leptospira outer membrane proteins (OMPs) may elicit tubular injury and inflammation through Toll-like receptor dependent pathway followed by activation of nuclear transcription factor kappa B (NF-kB) and mitogenactivated protein kinases (MAPK) and a differential induction of chemokines and cytokines relevant to tubular inflammation. The drugs available for this disease have shown no successful result, so in this work we aim at discovering natural and synthetic products as new leads in pharmaceutical development using many commercial softwares such as Accelrys Discovery Studio 3.5, Biosolve-IT and GOLD 5.1 suite for the molecular docking studies. For this, 50 natural and 50 synthetic compounds having anti-cancerous, anti-inflammatory, anti-microbial activity were derived from research articles and databases. Then by the docking results, comparative analyses between the natural and synthetic compounds were made to find the best compound among them. By the study, the natural compounds Sodium curcuminate and curcumin which belongs to same family of curcuma longa as well as Gemichalcone_B are the probable compounds for leptospirosis.

Author(s): Nair Vandana P N S Hamsa Chandramohan Vivek Patel Seema J

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Google scholar citation report
Citations : 7538

International Journal of Drug Development and Research received 7538 citations as per google scholar report

International Journal of Drug Development and Research peer review process verified at publons
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image


tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet

rolex replica