The objective of the present study was to develop sustained release matrix tablets of Pregabalin for the treatment of neuropathic pain and epilepsy. The tablets were prepared by wet granulation and formulated using drug with Hydrophilic, hydrophobic, synthetic, natural polymers and 4 different fillers were used. The effect of Polymer concentration, combination and fillers on drug release rate was analyzed for the formulations F-1 to F-17. The tablets were subjected to physicochemical studies, in-vitro drug release, kinetic studies and stability studies. The physicochemical properties of tablets were found within the limits. The prepared tablets were analyzed by using FTIR, DSC, SEM and stability studies. Between drug and polymer no interaction were detected from the FTIR and DSC studies. Gel formation and pores formation increased in diameter with time observed from Scanning electron microscope study (SEM). The mechanism of drug release from formulation F-15 was Anomalous (non-Fickian) diffusion. Optimized formulation F-15 was stable after stability studies in accelerated temperature and humidity.