In Vitro comparisons of anti-diabetic activity of flavonoids and crude extracts of Azadiracta indica A Juss

Indian medicinal plants used in the Ayurveda traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Alpha amylase inhibitors offer an effective strategy to lower the level of postprandial hyperglycemia via control of starch breakdown. Different crude extracts of Azadiracta indica A Juss have been considered as hypoglycemic agents. In this study, we compared the alpha amyse inhibitory activities of flavonoids with different crude extracts isolated from Azadiracta indica A Juss collected from Jaipur and Bharatpur districts of Rajasthan which sears approximately similar climatic conditions. Water, methanol, ethanol, acetone, toluene and petroleum ether were used for crude extraction. Alpha amylase inhibitory activities were evaluated by both qualitative and quantitative assays. Results showed that flavonoids have very high anti-diabetic potentials than crude extracts. IC50 values of flavonoids are 0.009g/ml and 0.006 g/ml in Jaipur and Bharatpur districts respectively while the IC50 values of other crude extracts are very high.

Author(s): Jain Chitra, Kumar Padma, Singh Archana & Jindal Alka

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