Hepatitis is one of the major health problems in human which sometimes may lead to even death. Natural products may be the best source of remedies for the treatment of liver diseases. Thus identification of a potential therapeutic agent for the protection of liver from the hepatotoxins will provide a useful way for the prevention of these liver related illnesses. Our studies identified a plant with potential hepatoprotective activity. The etanolic extract of Clerodendron inerme leaves were screened for its hepatoprotective activity in paracetamol induced liver damage in Swiss albino rats at a dose of 200 mg/kg bw. The etanolic extract exhibited a significant protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and total bilirubin. Liv.52 was used as positive control. The effects of the drug was judged by changes in serum marker ALT, AST, ALP, Protein and bilirubin levels. The extract did not show any mortality up to a dose of 2000g/kg bw.