Abstract

FORMULATION OF FLOATING TABLETS OF MEFENAMIC ACID WITH DIFFERENT GRADES OF HYDROXY PROPYL METHYL CELLULOSE POLYMER AND STUDYING THE RELEASE PROFILES

Hydrodynamically balanced system (HBS) or Floating tablets has gained importance in recent days to improve absorption of drugs especially those that are absorbed from stomach and small intestine. In the present study, an attempt was made to fabricate and evaluate an HBS dosage form of Mefenamic Acid tablet The different viscosity grades of Hydroxypropylmethyl cellulose polymer like HPMC K100, HPMC K4M, HPMC KV600, HPMC K50 was incorpated as hydrophilic swellable polymers for preparing matrix-floating tablets. Sodium bicarbonate was incorporated as a gas-generating agent. The prepared floating tablets were evaluated for the physical parameters like thickness, hardness, friability, drug content, floating lag time, floating time and Invitro dissolution studies. The mechanism of drug release was anomalous type and depends upon the viscosity of polymers, which was mainly concluded as the major controlling factor for the drug release. The results showed that the formulation containing Drug: Hpmc kv600 in the ratio of 1:0.5 is suitable for the formulation of gastroretentive floating tablets of mefenamic acid


Author(s): Ramanathan.G, Kavitha.K, Archana T.N, Nalini C.N, and Anandkumar M.A

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