The aim of the current study is to develop and evaluate patient friendly taste masked oro-dispersible tablets of Perindopril Erbumine. Perindopril is an antihypertensive drug and is used in the management of hypertensive urgency. The bitter taste of the drug and the fact that it being a pro-drug needs to be converted to active metabolite after being absorbed emphasizes on the need for improvement in patient compliance and improvement in disintegration time in order to enhance the onset of action. Taste masking is done by using polymethacrylate co-polymer by mass extrusion technique. The preliminary batches were prepared by using different superdisintegrants like Ac-Di-Sol, Primogel, Tulsion-335 and Tulsion-339. From the preliminary study it was found that orodispersible tablets containing Ac-Di-Sol showed better disintegration time and it was considered for further studies. A 32 full factorial design was applied to optimize the formulations, nine batches were prepared and evaluated. It was observed from the evaluations that the batch A2 showed the best disintegration time and also completes drug release within five minutes. Hence it was concluded that orally disintegrating tablets of Perindopril Erbumine can be successfully formulated using Ac-Di-Sol.