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Formulation, Development and Evaluation of Sustained Release Matrix Tablet of Antihypertensive Drugs

The current study was focus on to the formulation of sustain release tablet of Diltiazem. Diltiazem is calcium channel blocker was used for the treatment and management of high blood pressure, chronic stable angina. Diltiazem having the short half-life i.e., 3.0 to 4.5 hours and it is also having low bioavailability so that need to develops the controlled release tablet. The aim of this study was to provide sustained action, reduce the frequency of dose administration and increase bioavailability, reduce the dose dumping and increase patient compliance. Dry granulation method was used to the preparation of the matrix sustain release tablet. By using different polymers, the drug release extended up to the 24 hours. The drug-excipient compatibility study was done by using the FTIR studies. The evaluation of tablets was done by using various parameters like bulk density, tapped density, Angle of repose, Hauner’s ratio, Carr’s index, thickness, weight variation, friability, Disintegration and dissolution studies. The formulation F9 gives better result it release drug up to 24 hours.


Nikhil Arun Shete, Vaijayanti Lokhande, Pradnesh Mane and Sachin Yelawande

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