In present research work, dispersible tablets of cefpodoxime proxetil were formulated using direct compression technique. Cefpodoxime proxetil is an advanced-generation, broad-spectrum cephalosporin antibiotic approved for the treatment of acute bacterial exacerbation of chronic bronchitis (AECB), group-A betahemolytic streptococcal pharyngotonsillitis, and uncomplicated skin/skin structure infections in adult and adolescent patients. Cefpodoxime proxetil has slightly bitter taste and has poor water solubility. So in case of acute bacterial exacerbation of chronic bronchitis (AECB) group- A beta-hemolytic streptococcal pharyngotonsillitis, and uncomplicated skin/skin structure infections it require immediate release of drug from the dosage form, which make Cefpodoxime proxetil suitable candidate for dispersible tablets. In this research work, dispersible tablet for Cefpodoxime proxetil was made by Direct Compression, Croscarmellose sodium used as a superdisintegrant. It is concluded that physical parameters like hardness, thickness has significant effect on the performance of the dispersible tablet, so such parameter are critically maintained or put at their optimum level during the manufacturing of the dispersible tablets to obtain desired properties of dispersible tablets. F8 formulation shows superior result then other formulation disintegration time, cumulative percentage drug release and dispersion time were 47 seconds, 97.7% and 16 seconds respectively. Thus F8 formulation gives better disintegration time, optimum friability and drug release then other formulation.