Formulation and Release behavior of sustained release Stavudine Hydrochloride Matrix tablet containing Hydrophilic and Hydrophobic Polymers

Stavudine is an antiviral drug which is used in the control of HIV and tuberculosis therapy. There are considerable inter-individual variations in serum concentration of stavudine due to short half-life. In this study, stavudine was therefore selected as the model drug and effects of different polymers (Eudragit RSPO, Eudragit RLPO and Hydroxypropyl methylcellulose) in differing combinations and ratios were studied on swelling behavior of the tablets and release pattern of stavudine from the formulations. All tablets were acceptable with regard to thickness, weight variation, hardness, and drug content. The formulation (F7) having combination of Eudragit RSPO and Eudragit RLPO (1:2) and 10% hydroxypropyl methylcellulose showed 208.21 + 0.66 % swelling, 48.33 + 1.49 % erosion and 90.43 ± 1.11% drug release. Maximum release was observed by increasing the content of Eudragit RLPO. Optimized formulations were subjected to stability studies for six months which showed stability with regards to release pattern.

Author(s): Khan Shagufta, Charhate Kishor, Singhavi Dilesh, Yeole Pramod

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Flyer image
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs


tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet