Formulation and Evaluation of Taste Masked Cetrizine Dihydrochloride Orally Disintegrating Tablets: A Research

Oral routes of drug administration have wide acceptance up to 50-60% of total dosage forms. ODTs dissolve or disintegrate instantly on the patients tongue or buccal mucosa and leaves easy-to-swallow residue. It is suited for tablets undergoing high first pass metabolism and is used for reducing dosing frequency. New ODT technologies address many pharmaceutical and patient needs such as, it denotes its importance in case of pediatric, geriatric and patients suffering from nausea or repeated emesis conditions, bed-ridden patients having dysphagia. So taste masking is essential criteria following the advanced method of use of ion exchange resins. Research in developing orally disintegrating systems has been aimed to investigate different excipients as well as techniques to meet number of challenges. Orally disintegrating tablets are the safest, convenient and highly economical formulations. They show satisfactory absorption from oral mucosa; ultimately immediate pharmacological action. This research deals with formulation of orally disintegrating tablets by direct compression inorder to achieve a better dissolution rate and further improving the bioavailability of the drug. The result showed rapid dissolution of drug with the use of superdisintegrants, Ac-di-sol (Disintegration Time [DT] 5-6 sec.) as compared to sodium starch glycolate (DT 8-9 sec.) and polyplasdone (DT 8-10 sec.).

Author(s): Smita Kolhe, Apurva Deshpande,Dhananjay More

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