The present research was engrossed on the development and evaluation of sustained release pellets of Domperidone with different grades of ethyl cellulose like ethyl cellulose N10, N7 and N20 by employing drug layering technology. Pellets were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results.Formulation was optimized on the basis of acceptable pellet properties (friability, drug content moisture content and loss on drying) and in-vitro drug release. The in-vitro release studies of pellets were carried out in 0.1N HCL for 2 hours and 6.8 PH phosphate buffer for 12 hours. The studies indicated that the drug release can be modulated by varying the concentration of the polymer. The formulations were further characterized to identify any possible interactions by FTIR spectroscopy and differential scanning calorimetry. The nature of the drug and the optimized formulation was determined by X-Ray diffraction. The surface morphology of the pellets was studied by scanning electron microscopy.