Formulation and Evaluation of Fast Dissolving Oral Film of Dicyclomine as potential route of Buccal Delivery

Buccal delivery is considered to be an important alternative to the peroral route for the systemic administration of drugs, as it considered the most convenient, easy, safest route of administration. Oral mucosa has rich vasculization, offers better permeability to many drugs & it act as an excellent site for the absorption of drugs. Fast dissolving oral film (FDOF) is used as a novel approach, as it dissolve rapidly in mouth and directly reaches to the systemic circulation. Oral film technology fulfills all the requirements of potential solid dosage form. The aim of this study is to formulate and evaluate the (FDOF) of an anticholinergic drug (Dicyclomine) and improved bioavailability of drugs as compared to conventional solid oral dosage forms. Oral films were prepared by using HPMC (hydroxypropylmethylcellulose), PVA (polyvinylalcohol), Eudragid RL-100, combination of two polymers and other excipients. Films were prepared by the solvent casting method. Films were evaluated for mechanical properties, Morphology study, swelling properties, disintegration time, dissolution time and in- vitro drug release. X1 formulation shows maximum in- vitro drug release 93.88%, following first order kinetics (r2 =0.9915). The release exponent ‘n’ was found to be for X1 is 0.4487, which appears to indicate a Fickian diffusion and may indicate that the drug release was controlled by first order release.

Author(s): Alka Tomar, Kiran Sharma, Nitesh S Chauhan, Ashu Mittal, Umakant Bajaj

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