In the present work an attempt has been made to prepare FDT of Lomefloxacin HCl with an view to enhance the patient compliance, and provide a quick onset of action, increasing the solubility and masking its bitter taste. Taste masking and solubility was enhanced by complexing Lomefloxacin HCl with hydroxyl propyl β cyclodextrin (HP-βCD) by solvent evaporation method. Prepared complex was further compressed into tablets by direct compression using different superdisintegrant like Sodium starch glycolate, Croscarmellose sodium, Polyplasdone XL-10 in different concentration such as 1%, 1.5%, 2 % using aspartame as a sweetener and aerosil as lubricant. The drug release from FDT increase with increasing the concentration of superdisintegrants and was found to be highest with formulation F6 containing 1.5 % Croscarmellose Sodium and was consider to be the best formulation which release upto 100.68 % in 45 min. In vivo studies revealed that FDT of formulation (F 6) showed good bioavailability compared to conventional tablet. The fast dissolving tablet with HP-βCD complex can be formulated using different superdisintegrants by Direct Compression technique and was found to be disintegrate less than 2 minute, which provide faster effect and better patient compliance.