Reach Us 44-7452-259145

Abstract

Formulation and Evaluation of Colon Targeted Tablets of Ornidazole For The Treatment Of Amoebiasis

Ornidazole is used for the management of amoebiasis. The site of absorption of Ornidazole is in the whole GI tract and has a long half life of 13 h. The aim of the study was to develop colon targeted film coated tablets of Ornidazole using HPMC K100, Eudragit S 100, and Ethyl cellulose as carriers in the treatment of amoebiasis. All the formulations (F1 to F8) were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Ornidazole released from tablets at different time intervals was estimated by UV spectrophotometer. The formulation F7 released 99.38 % of Ornidazole. The results of the study showed that formulation F7 is most likely to provide targeting of Ornidazole for local action in the colon owing to its minimal release of the drug in the first 5 h. The most satisfactory formulation was stable during stability studies conducted for 60 days as per ICH guidelines. It showed no significant changes in the physicochemical parameters, in vitro release pattern.


Author(s): Pragnesh Pate, Anupkumar Roy, Vinod Kumar SM, Martand Kulkarni

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Google scholar citation report
Citations : 7472

International Journal of Drug Development and Research received 7472 citations as per google scholar report

International Journal of Drug Development and Research peer review process verified at publons
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image

tempobet

tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet
https://wowcappadocia.com
https://cappadocia-hotels.com
https://balloon-rides.net

https://paperio-live.com

rolex replica

https://agario.red

https://naughtyworms.com

Vaporesso
https://www.unitedluxury.net/