In this context, a polymer surface encompassed capsule dosage form of capecitabine was investigated and personalized for colon-targeted delivery of drugs. The sandwich replica of the system was designed by imparting the essences of time-release function and a pH-sensing function to a hard gelatin capsule. The technical traits of the system are fabricated to contain an organic acid together with an active ingredient in a capsule coated with a three-layered film consisting of an acid-soluble polymer, a water-soluble polymer, and an enteric polymer. In order to prioritize the suitable formulation, various formulation factors were investigated through a series of in vitro dissolution studies. The results are complied as: (1) various organic acids can be used for this system invariably; (2) a predictable timed-release mechanism of a drug can be attained by tailoring the thickness of the Eudragit E 100 layer; and (3) the outer enteric coating with CMEC lends acceptable acid-resistibility. The result out comes postulate and suggests that this approach can provide a beneficial and practical means for colon-targeted delivery of drugs. This engineered structure has a proven benefit in various fronts for the end organ (colon), getting optimum concentration of drug to cause the therapeutic improvisation in the segment of malignancy and its associated risks within it.