FORMULATION AND COMPARISON OF SUSPENDING PROPERTIES OF DIFFERENT NATURAL POLYMERS USING PARACETAMOL SUSPENSION

The present study aims to search for a cheap and effective natural excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions. So in this research suspending properties of different natural polymers were evaluated comparatively with each other .Tamarind seed polysaccharide, Tragacanth, Acacia and Gelatin at concentration range of 1 ? 4.5%w/v are used to prepare paracetamol suspension. Characterization tests were carried out on each of polysaccharide. Sedimentation volume (%), rheology and particle size analysis were employed as evaluation parameters. The values obtained there from, were used as basis for comparison of the suspending agents studied. Results shown that the suspending ability of all the materials was found to be in the specific order: Compound Tragacanth gum > Acacia gum > Gelatin > tamarind seed polysaccharide. At all concentrations employed, compound Tragacanth gum had the strongest suspending ability relative to the other materials. The findings of the results suggest that, due to the high viscosity of compound tragacanth gum, it can be a stabilizer of choice when high viscosity is desired. It can also serve as a good thickening agent in both pharmaceutical and food industries.

Author(s): Malviya Rishabha, Srivastava Pranati, Kumar Upendra, C.S. Bhargava, Sharma Pramod Kumar

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