The buccal region offers an attractive site of administration of drugs for systemic use. A buccal drug delivery system was developed for Prochlorperazine, a dopamine D2 receptor antagonist with antiemetic property using HPMC (15 and 47 cps), ethyl cellulose, and PVP. The prepared patches were characterized by means of film thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling behaviour, percentage moisture loss, tensile strength, percentage elongation, surface pH, Invitro studies, exvivo mucoadhesion studies and Invivo absorption studies to determine the amount of drug release from selected films. In vitro release studies of drug-loaded patches in phosphate buffer solution (pH, 6.6) exhibited drug release in the range of 35.64 to 72.33% in 30 min. In vivo studies on rabbits showed 80.40% of drug absorption from the patches containing HPMC and PVP as a polymer. Good correlation among in vitro release and in vivo studies was observed. Short-term stability study on the films revealed no significant changes in drug content and release studies after 4 weeks. The findings suggest that the present prochlorperazine maleate containing buccal film could be potentially useful to control the emesis induced by anti-cancer agents or opioid analgesics in patients who limit the oral intake.