The Mangifera indica dried leaves were Soxhlet extracted by the solvent methanol and a clay type sticky extract was obtained. This was used in this research work after some chemical verification. There were two screening model systems used to evaluate the anti-inflammatory activity of the extract, mainly cotton pellet granuloma technique (for chronic inflammation) and carrageenan induced paw edema technique (for acute inflammation). Granuloma pouch is mainly used for assessing the drugs for their topical use rather than parenteral use. Granulation formation is one of the key features in chronic inflammation. Acute inflammatory conditions can be produced in laboratory animals by using various phlogistic agents (e.g., Carrageenan); however, duration of these inflammatory conditions is quite transitory and these inflammatory conditions can easily be controlled by using currently available antiphlogistic agents. The present pharmacological study was undertaken to evaluate the possible anti-inflammatory properties of the aqueous methanolic leaf extract from Mangifera indica. The study was therefore aimed at investigation of the anti-inflammatory activity of leaf extract with a view to justifying the use of the plant in the treatment of inflammatory diseases.