The controlled release dosage form is now a days getting more attraction than the conventional dosage form. In the recent study, our aim was to develop the CR tablets of Mefenamic Acid (NSAID). In this study Methocel K100 M Premium EP was used as polymer to control the release of drug from the tablets. Three different formulations were designed by changing the ratio of the drug to polymer ratio. The dissolution profiles and the release kinetic studies reveal that the designed formulations fulfill the requirements for the controlled release dosage form. Hence, the designed formulations can successfully be used for the commercial production of the controlled release tablets of the Mefenamic Acid.