Evaluation of Anti-Depressant Activity of Ethanolic Extract of Justicia gendarussa Burm with Wister Rat

Objective: Justicia gendarussa Burm is an herbal plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated anti-depressant effect of ethanolic extract from Justicia gendarussa Burm by using Forced Swimming Test (FST).

Methods: Two doses of ethanolic extract of Justicia gendarussa Burm (250 mg/kg and 500 mg/kg) was injected intraperitoneally. Immobility time and swimming time were measured after 30 min of injection and compared with negative control and imipramine as a positive control.

Results: The ethanolic extract (500 mg/kg) was found to be effective and it exhibited activity similar to that of the conventional drug imipramine (p<0.001) whereas 250 mg/kg dose showed higher activity with significantly increased swimming time and decreased immobility time than 500 mg/kg of ethanolic extract and imipramine.

Conclusion: These results proposed 250 mg/kg of ethanolic extract was showed higher anti-depressant activity than the standard.



Mythili A and Jothimanivannan C

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Flyer image
Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs


tempobet giriş

tempobet giriş

tipobet süpertotobet yeni adres süperbahis 747 güvenilir bahis siteleri telefonda sex sohbet