The ancient Egyptians were familiar with many medicinal herbs and aware of their usefulness in treatment of various diseases. Eucalyptus oil is used to control several diseases derived from microbial infections. Eucalyptus oil has been suggested for many other uses, based on tradition or on scientific theories. However, these uses have not been thoroughly studied in human, and there is limited scientific evidence about safety or effectiveness. Eucalyptus oil and its major component 1,8-cincole have antimicrobial effects. In this review, an unusual and a rare case of chemical injury secondary to the use of eucalyptus oil has been presented here.